By M.D. Esben Kirk
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Extra info for Acidosis. Clinical Aspects and Treatment with Isotonic Sodium Bicarbonate Solution
Aren. f. , 71: 61, 1934. further work impossible and will thus become a limiting factor in the output of work. This circumstance will also be of importance in athletics and sports in setting a limit to the possible reduction of the times of world records in certain sports events. In some cases it seems possible to improve the record by administration of bicarbonate, whereas conversely, the maximal output of work will be reduced with a preexisting considerable acidosis (e. g. acidosis due to medication).
2 the background that they were made in a country where cholera is endemic and where there are, therefore, opportunities of examining a great number of patients. Thus an article180 in The Lancet from 1921 is based on 2000 cases. Compared with this two European works on the treatment of cholera from the beginning of the great war by Rosenthal185 and Elias,41 must be termed modest, but they merit attention because the authors had no knowledge of Sellards' and Rogers' investigations, but, on the basis of their own observations on the clinical picture of the disease, instituted intravenous treatment with bicarbonate solution.
This is probably due to the fact that O'Shaughnessy shortly before on a more speculative basis had proposed another therapy for cholera, viz. « Lancet 1, 366, 1831-32). O'Shaughnessy had hardly any opportunity of trying this treatment, which is only a matter for satisfaction, since it might have brought discredit on the intravenous sodium chloride bicarbonate therapy. Latta was beyond doubt the first to introduce the intravenous treatment in cholera (Lancet 2, 1831-32, and 2y 286, 1831-32) but he emphasises that it is the plasma analyses of O'Shaughnessy that have given him the idea of this treatment (Lancet 2, 275, 1831-32).