By Alton Meister
Advances in Enzymology and similar parts of Molecular Biology is a seminal sequence within the box of biochemistry, delivering researchers entry to authoritative studies of the newest discoveries in all parts of enzymology and molecular biology. those landmark volumes date again to 1941, offering an unmatched view of the old improvement of enzymology. The sequence bargains researchers the most recent realizing of enzymes, their mechanisms, reactions and evolution, roles in complicated organic procedure, and their program in either the laboratory and undefined. each one quantity within the sequence positive factors contributions through best pioneers and investigators within the box from around the globe. All articles are rigorously edited to make sure thoroughness, caliber, and clarity.
With its wide selection of subject matters and lengthy old pedigree, Advances in Enzymology and comparable parts of Molecular Biology can be utilized not just through scholars and researchers in molecular biology, biochemistry, and enzymology, but in addition via any scientist attracted to the invention of an enzyme, its homes, and its purposes.
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Extra info for Advances in Enzymology and Related Areas of Molecular Biology, Volume 35
Compound One-carbon THE BIOSYNTHESIS OF PTERIDINES 49 precursors of pteridines was supplied by Brenner-Holzach and Leuthardt (34,35) in Drosophila melanogaster and Weygand et al. (36)) who showed that guanine or guanosine is probably converted directly to xanthopterin in the butterfly, Pieris brassica L. Finally, Vieira and Shaw (37) showed that a purine (adenine) labeled with l4C was converted to the pteridine component of folic acid with no significant dilution in specific radioactivity. This indicated conclusively that a purine functions as a direct precursor of pteridines.
Plantarum (47), Salmonella typhimurium (54), a species of Pseudomonas (55) (more recently described as Comamonas [561), and Pseudomonas cocovenenans ( 5 7 ) and also from spinach leaves (50). Formic acid has been identified as the 1-carbon compound derived from carbon 8 of the guanine nucleotide in these systems, and GTP is the specific nucleotide used as substrate 'in all cases where precautions have been taken to keep ATP out of the reaction mixtures. The previous observations that guanosine, GMP, and GDP could act as substrate can be explained by the presence of 55 T H E BIOSYNTHESIS O F PTERIDINES ATP in the reaction mixtures which allows GTP t o be produced from guanosine, GMP, and GDP.
36)) who showed that guanine or guanosine is probably converted directly to xanthopterin in the butterfly, Pieris brassica L. Finally, Vieira and Shaw (37) showed that a purine (adenine) labeled with l4C was converted to the pteridine component of folic acid with no significant dilution in specific radioactivity. This indicated conclusively that a purine functions as a direct precursor of pteridines. The transformation of a purine to a pteridine requires extra carbon atoms to be supplied for completion of the pteridine ring structure (see Fig.