By A. G. Fishburn
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Extra resources for An Introduction to Pharmaceutical Formulation
An oxidase complex is also present and causes incompatibility with certain phenolic compounds and alkaloids; it can be destroyed by heat. Acacia is used either as a powder or as a ready-made mucilage containing the equivalent öf about 35 per cent w/v of gum. In making solutions, " t e a r s " are preferable to powder both from the viewpoint of quality and for ease of handling; water does not penetrate the powder readily, due to rapid swelling of the outer layers. Solutions require an antimicrobial preservative such as chloroform or benzoic acid.
CH< ^4H9 S0 3 Na This is a white, waxy solid, very soluble in alcohol and in glycerin but only sparingly soluble in water (1 in 70). It is used as a wetting and an emulsifying agent and is known under several trade names, notably "Aerosol OT". It can be administered by mouth in quantities up to 100 mg and is sometimes given as a faecal softener. Na This has not been defined in a monograph but is used in concentrations of about 1 per cent in dispersible powders to promote rapid wetting, and also in tablets of highly insoluble drugs to promote disintegration and wetting.
C. Sodium alginate does not occur naturally as such but is obtained by extracting various species of Laminaria and other brown seaweeds with dilute alkali. Its composition is not known precisely b u t alginic acid is usually described as a polyuronic acid containing residues of D-mannuronic acid. Both alginic acid itself and sodium alginate are used industrially as thickeners and binders but the sodium salt is usually preferred in the food and drug industry. This is available as an off-white to yellowish-brown powder containing u p to 22 per cent of moisture ; it is virtually tasteless a n d odourless.