By H.-L. Krüskemper (Auth.)

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In addition to the question of the dissociation of the anabolic and androgenic activities of anabolic steroids, w h o s e exact definition in m a n p o s e s p r o b l e m s , there is also the interesting question as to the local differences of these various anabolic steroids in their extragenital activity, which would permit a well-aimed, therapeutic application of the individual anabolic steroids. Investigations in this direction have not yet been made. W e h a v e noted the basic similarity b e t w e e n the nitrogen-retaining activity of natural androgens and that of synthetic anabolic steroids.

0 mg/kg (72) 0 . 3 - 3 . 0 mg (1134) 0 . 0 5 - 1 . 0 mg (1177) 17a-Methyl-4,17/3-dihydroxyandrost-4-en-3-one 19-Nortestosterone cyclopentylpropionate 17a-Ethyl-17/3-hydroxy-19norandrost-4-en-3-one la-, 17a-Dimethyl-17/3-hydroxyandrost-4-en-3-one D L - 13/3,17a-Diethyl-17/3-hydroxygon-4-en-3-one 71 1 Rat, 9 adult Rat, castrated Rabbit Rat, & castrated Rat, d castrated Rat,

S u b s t a n c e s to be tested h a v e to be injected for a long enough period of time. Seminal vesicles react so slowly to certain androgens that in short tests (7 days) distortions can arise in the favor of the myotropic effect. F o r example, testosterone cyclopentylpropionate hardly affected the seminal vesicle during a 17-day experiment, w h e r e a s in the c o u r s e of 30 days it w a s the m o s t active of several steroids tested (223). F o r the s a m e reason it is useless to c o m p u t e a myotropic-androgenic ratio w h e n a slowly cleaved 17/3-ester is c o m p a r e d with a free steroid, or a 17/3-acetate, or a 17/3-propionate in a short experiment with daily injections.

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